Part of the Biotechnology: Pharmaceutical Aspects book series (PHARMASP, volume X) Supercritical Fluid Technology for Nanotechnology in Drug Delivery. About this book. The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of. download Nanomaterials for Drug Delivery and Therapy - 1st Edition. Print Book & E-Book. ISBN ,
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This book is an open-access book distributed under the terms and conditions of the. Creative . Barriers to central nervous system (CNS) drug delivery  .. Applications of nanotechnology in diabetes. This book collects reviews and original articles from eminent experts working in the interdisciplinary arena of nanotechnology use in drug. Centre for Nanomedicine and Biophysical Drug Delivery, National Institute for Nanotechnology definitely promises to serve as drug delivery carrier of choice for Related Content. This Book. IntechOpen. Recent Advances in Novel Drug.
In particular silica nanoparticles are inert from the photophysical point of view and might accumulate a large number of dye s within the nanoparticle shell.
About this book
Multicolor optical coding for biological assays has been achieved by embedding different-sized quantum dots into polymeric microbeads. Nanopore technology for analysis of nucleic acids converts strings of nucleotides directly into electronic signatures.
The smaller the incisions the faster the healing time which is better for the patients. It is also helping to find a way to make an arthroscope smaller than a strand of hair.
The results promise to be highly accurate and the product promises to be inexpensive.
Application of Nanotechnology in Drug Delivery
They could take a very small amount of blood and detect cancer anywhere in the body in about five minutes, with a sensitivity that is a thousand times better a conventional laboratory test. These devices that are built with nanowires to detect cancer proteins; each nanowire detector is primed to be sensitive to a different cancer marker.
They have found ways that they will be able to target a specific part of the body that is being affected by cancer. The technology is available under the name Magnetic-activated cell sorting or Dynabeads among others. More recently it was shown in animal models that magnetic nanoparticles can be used for the removal of various noxious compounds including toxins , pathogens , and proteins from whole blood in an extracorporeal circuit similar to dialysis.
Nanotechnology in Drug Delivery
Additionally larger compounds which are commonly not dialyzable can be removed. These binding agents are able to interact with target species forming an agglomerate. Applying an external magnetic field gradient allows exerting a force on the nanoparticles. Hence the particles can be separated from the bulk fluid, thereby cleaning it from the contaminants. These advantages are high loading and accessible for binding agents, high selectivity towards the target compound, fast diffusion, small hydrodynamic resistance, and low dosage.
It can also be used to selectively remove cytokines or endotoxins  or for the dialysis of compounds which are not accessible by traditional dialysis methods.
However the technology is still in a preclinical phase and first clinical trials are not expected before Tissue engineering if successful may replace conventional treatments like organ transplants or artificial implants.
Nanoparticles such as graphene, carbon nanotubes, molybdenum disulfide and tungsten disulfide are being used as reinforcing agents to fabricate mechanically strong biodegradable polymeric nanocomposites for bone tissue engineering applications.
This could be used to weld arteries during surgery. Medical devices[ edit ] Neuro-electronic interfacing is a visionary goal dealing with the construction of nanodevices that will permit computers to be joined and linked to the nervous system. This idea requires the building of a molecular structure that will permit control and detection of nerve impulses by an external computer.
A refuelable strategy implies energy is refilled continuously or periodically with external sonic, chemical, tethered, magnetic, or biological electrical sources, while a nonrefuelable strategy implies that all power is drawn from internal energy storage which would stop when all energy is drained.
A nanoscale enzymatic biofuel cell for self-powered nanodevices have been developed that uses glucose from biofluids including human blood and watermelons.
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FAQ Policy. Show all. Pages Nanomaterials and Biocompatibility: Moein et al. Controlled Release and Nanotechnology Betancourt, Tania et al.
Nanotechnology in Drug Delivery: Past, Present, and Future Kim, Sungwon et al.Assesses the opportunities and challenges of nanotechnology-based drug delivery systems Explores how nanotechnology is being used to create more efficient drug delivery systems Discusses which nanomaterials make the best drug carriers. This book shares a lifetime of lessons from my pioneering efforts in compound custom formulating.
Nanotechnology-based drug delivery systems
Two principal factors cause the properties of nanomaterials to differ significantly from other materials: Keservani, MPharm Anil K. Innovations in Chemical Physics and Mesoscopy. The common techniques for characterization as summarized by B. Pulmonary administration Micronization of drugs plays an important role in improving the drug dosage form and therapeutic efficiency today.
The circulation times of these drugs have increased substantially by conjugation with polymers, such as PEG.
Together the insightful research presented here provides valuable information for those involved in this area, including scientists and researchers, faculty and upper-level students, as well as for industry professionals. It has been suggested [ 1 , 2 ] that, organ or tissue accumulation could be achieved by the passive or antibody-mediated active targeting [ 3 , 4 ], while the intracellular delivery could be mediated by certain ligands [ 5 , 6 ] or by cell-penetrating peptides [ 7 , 8 ].