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Antimicrob Agents Chemother. Effectiveness of the local or oral delivery of the novel naphthopterocarpanquinone LQB against cutaneous leishmaniasis. J Antimicrob Chemother. Leishmaniasis: treatment updates and clinical practice guidelines review.

Curr Opin Infect Dis. Novel targeting using nanoparticles: an approach to the development of an effective anti-leishmanial drug-delivery system. Int J Nanomedicine. High mortality among older patients treated with pentavalent antimonials for visceral leishmaniasis in East Africa and rationale for switch to liposomal amphotericin B.

Bioorg Med Chem. Eur J Med Chem. Effects of nitro-heterocyclic derivatives against Leishmania Leishmania infantum promastigotes and intracellular amastigotes.

Exp Parasitol. Synthesis and biological activity of nifuroxazide and analogs. Boll Chim Farm. Molecular modeling studies and in vitro bioactivity evaluation of a set of novel 5-nitro-heterocyclic derivatives as anti-T.

Trouiller P, Olliaro PL. Drug development output from to what proportion for tropical diseases? Int J Infect Dis.

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Quinone-amino acid conjugates targeting Leishmania amino acid transporters. Exploring 5-nitrofuran derivatives against nosocomial pathogens: synthesis, antimicrobial activity and chemometric analysis. Chemotherapy of Trypanosoma gambiense and Trypanosoma rhodesiense infections in guinea pigs with nitrofurazone.

Am J Trop Med Hyg. Effect of Apigenin on Leishmania siteensis is associated with reactive oxygen species production followed by mitochondrial dysfunction. J Nat Prod. Activity of Thymus capitellatus volatile extract, 1,8-cineole and borneol against Leishmania species. Vet Parasitol.

Antimicrobial peptide-induced apoptotic death of Leishmania results from calcium-dependent, caspase-independent mitochondrial toxicity. J Biol Chem. Cell death and ultrastructural alterations in Leishmania siteensis caused by new compound 4-Nitrobenzaldehyde thiosemicarbazone derived from S-limonene.

BMC Microbiol. In vitro activities of ER and E, two potent squalene synthase inhibitors, against Leishmania siteensis: antiproliferative, biochemical, and ultrastructural effects. In vitro antileishmanial activity and cytotoxicity of essential oil from Lippia sidoides Cham.

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Zapata-Torres, M. Biggin, B. Partheil, Arch. Freund, A. Friedmann, Ber. Rouden, V. Tadino, M. Lasne, Org. Sheldrick, Program for the Refinement of Crystal Structures. University of Gottingen, Germany. Visual Crystal Structure Information System.

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Coe, P. In its structure two rings form a bispidine framework that is fused to a 3-nitropyridone group. The two independent molecules in 1 form intermolecular interactions.

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