Read "Lupus Q + A (Revised Edition)" by Robert G. Lahita available from Rakuten Kobo. Sign up today and get $5 off your first download. A rheumatologist and a. Systemic lupus erythematosus (SLE) is a multi-system autoimmune disorder .. initiating antigen from analyses of serological activities of serial SLE sera (8). The ePub format uses eBook readers, which have several "ease of reading" Lupus nephritis is a disease of mostly young females that puts them at high Treat-to-target induction therapy of lupus nephritis aims to suppress systemic . The clinical significance of serial kidney biopsies in lupus nephritis.
|Language:||English, Arabic, German|
|ePub File Size:||30.51 MB|
|PDF File Size:||19.29 MB|
|Distribution:||Free* [*Sign up for free]|
Systemic lupus erythematosus (SLE) is an autoimmune chronic inflammatory disease that affects multiple organs and tissues. Lupus nephritis. Lupus cystitis is a rare complication of systemic lupus erythematosus (SLE). It is characterized by an increase in bladder wall thickness and. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by development of autoantibodies to nuclear and cytoplasmic.
SLE is generally much more severe in Asians, and the incidence of renal involvement is especially high [ 6 ]. Although Indonesia comprise of more than ,, people, as to date, this is the first report of lupus cystitis from Southeast Asia compared to East Asian countries who generated numerous report of such rare SLE complication.
East Asian countries such as South Korea, Japan, and China are far more developed than most Southeast Asian countries, and this factor might contribute to a better reporting of rare SLE complications. The present case report is the first from the Southeast Asia region. Up to Gastrointestinal symptoms present in Immunohistochemical studies have revealed the deposition of IgG and C3 in the walls of the arterioles in the bladder and intestine, suggesting that a common autoantigen and chronic inflammation may be responsible for the co-occurrence of gastrointestinal and bladder symptoms in these patients [ 8 , 9 ].
Our patient was unusual, as she did not have any gastrointestinal symptoms. Lower urinary tract symptoms were also absent, although she did have bilateral hydronephrosis Fig. In an autopsy study, histological abnormalities were found in the bladder wall of an SLE patient who did not have lower urinary tract symptoms, showing that a silent progression of the disease is possible [ 10 ].
Zhang et al. The main finding in lupus cystitis is an increased thickness of the bladder wall due to chronic interstitial cystitis, with pathological examination showing deposition of immune-mediated complex in the bladder wall [ 7 , 11 ]. Ultrasonographic examination and a computed tomography scan may reveal bilateral hydronephrosis or hydroureteronephrosis in addition to bladder wall thickening [ 12 , 13 ]. Fibrosis of the ureterovesical junction and edema of the bladder wall caused by deposition of immune-mediated complex leads to decreased bladder capacity and detrusor muscle spasm, and the ensuing vesicoureteral obstruction and reflux has been suggested to be the cause of the hydronephrosis in our patient.
Ultrasonographic abnormalities were present in our patient, but she presented without any usual symptoms of cystitis lupus. Our patient also had lupus nephritis as shown by the high h urinary protein excretion. B-cell hyperactivity results in an increased autoantibody production and the deposition of antibody-antigen complex in target organs.
In the kidney, deposition is mostly at the base of the glomeruli, in the mesangial layer, and the interstitial tissue of the proximal tubules. This deposition activates a series of inflammatory cascades that result in glomerular damage and decrease in renal function. Lupus nephritis is more common and more severe in Asians, and Cheng et al. The authors also suggest that renal biopsy needs to be performed to accurately measure disease progression in patients with lupus nephritis.
SLE may be associated with menstrual cycle irregularities. Shabanova et al. According to the authors, SLE patients had lower estradiol and progesterone levels than healthy controls.
Such hormonal imbalances — as well as the thrombocytopenia that was detected — could explain the prolonged heavy bleeding during menstruation in our patient. Although the chief complaint of the patient was the prolonged and heavy bleeding, we could not determine a direct relationship between the occurrence of lupus cystitis with the menorrhagia in this patient, as no such report had stated such a relationship, and no further immunohistochemistry was planned to see the relationship in our patient.
Lupus ABG: Suster Ngepooot!
In conclusion, lupus cystitis is a rare manifestation of SLE and has mainly been reported from East Asian countries. To the best of our knowledge, this is the first report of lupus cystitis from the Southeast Asian region. Furthermore, our patient did not experience the common symptoms of lupus cystitis, as the chief complaints was only menorrhagia.
Thus, lupus cystitis should be suspected in SLE patients even in the absence of obvious lower urinary tract or gastrointestinal symptoms.
This is worth noting because lupus cystitis is a rare complication of SLE, which could progress silently without any symptoms. Therefore, we encourage all treating physicians to be more aware of possible bladder involvement in SLE. An abnormal urine sample and ultrasound examination should prompt evaluation of the patient for possible bladder involvement so that treatment can be instituted early and further complications can be prevented.
The Ethics Committee of the hospital and the university deemed ethical approval to be unnecessary. The author has no conflicts of interest to report in relation to the publication of this article. March 12, Accepted: August 20, Published online: September 18, Issue release date: September — December. For additional information: Usage and distribution for commercial purposes requires written permission.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions.
The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor s. The publisher and the editor s disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Karger International: Forgot your password? Institutional Login Shibboleth or OpenAthens For the academic login, please select your organization on the next page. Forgot Password? Sign up for MyKarger Institutional Login. Download Fulltext PDF.
Case Report. Related Articles for " ". Case Rep Nephrol Dial ;8: Go to Top Abstract. FullText PDF. Abstract Lupus cystitis is a rare complication of systemic lupus erythematosus SLE.
Lupus ABG: Suster Ngepooot! Boim Lebon.
Malam itu tiba-tiba badan Lulu panas banget. Karena panasnya nggak kunjung turun, akhirnya Mami minta Lupus membawa Lulu ke dokter.
Lupus nganter Lulu ke klinik 24 jam pake becak, tapi kliniknya sepi banget. Barusan saya kentut, tau! Tiba-tiba muncul seorang ibu tua memakai kain lusuh dengan rambut beruban. Selain itu muncul juga seorang suster yang ekspresi wajahnya sangat dingin.
Lupus dan Lulu makin merinding, dan akhirnya kabuuur! Tapi, apa betul di klinik yang sepi itu ada makhluk halusnya?
Terus, apa hubungannya dengan hantu paling populer abad ini: Suster Ngepooot? Get A Copy. Paperback , 60 pages. More Details Friend Reviews. To see what your friends thought of this book, please sign up.
To ask other readers questions about Lupus ABG , please sign up. Lists with This Book. This book is not yet featured on Listopia. Community Reviews.
International Codes of Nomenclature
Showing Rating details. More filters. Sort order. May 27, Klinik Rosa rated it it was amazing. Hubungi Saja Hotline Kami. Cara Pemesanan Webiste Resmi: View 1 comment.
May 18, bakanekonomama rated it really liked it Shelves: Hujan di luar mulai deras. Obrolan Lupus dan Prudence tiba-tiba terpututs setelah beberapa kali terdengar suara petir menyambar-nyambar dengan bunyi keras. Tolong dong kamu nganga! Maksud Mami? Masa sih ditadahin pake mulut? Pake ember aja deh. Yang membuat saya bernostalgia mengenang kembali kisah-kisah Lupus yang saya sukai dulu. Mulai dari kisah Lulu yang hampir dibully sama kakak kelasnya, Mami yang ngira Papi selingkuh gara-gara lipstik baru Lulu, sabotase katering Mami yang sudah mulai mendunia lsite Semua kisah yang ringan ini mampu membuat saya tertawa terpingkal-pingkal tanpa harus mikir.
Recent Advances in Treatment Strategies for Lupus Nephritis
Apalagi, Lupus ternyata masih sama kayak dulu. Masih doyan ngasih tebakan-tebakan jayus yang kadang bikin saya ngakak-ngakak, tapi kadang bikin saya pengen lempar sepatu saking jayusnya. Contohnya, ketika Lupus disuruh Mami untuk nganterin Lulu berobat ke klinik 24 jam.
Sempet-sempetnya Lupus ngerjain Mami-nya, seperti yang di bawah ini: Mana ada dokter yang buka? Mau naik becak kek, naik bajaj kek, terseraaah! Yang penting cepat adikmu bawa ke dokteeer!
Mami mulai panik. Tapi sebelum Lupus bawa Lulu ke dokter, tolong jawab dulu sebuah tebakan Udah panik begini masih ingat tebakan segala!
Nanti aja deh! Yang namanya karakter itu melekat pada diri seseorang, jadi kebiasaan main tebak-tebakan adalah salah satu karakter Lupus.
Jadi Mami harus mau menebak tebakan Lupus dulu. Cepat, cepat, mana tebakannya, manaaa? Kebetulan, akhir-akhir ini saya sedang malas luar biasa untuk membaca buku. Rasanya tuh, lagi suntuk aja.
Padahal, timbunan saya banyak banget. Makanya, saya memilih untuk membaca Lupus aja dulu, karena selain ceritanya ringan, nggak pake tebel juga. Saya beli buku ini sekitar dua minggu yang lalu di Festival Novel Gramedia itu, loh.
Sesuatu banget deh Nggak beli yang baru-baru. Selain Lupus, saya beli 5 Sekawan ini juga udah kangeenn buanget pengen baca lagi Sejarah, Silang Budaya, dan Masa Depan yang harganya hanya lima ribu sahaja Sayangnya, sejauh ini baru Lupus ABG saja yang sudah saya baca.
Padahal, libur panjang ini berharap dapat menghabiskan beberapa buku, tapi ternyata mood saya belum muncul juga untuk baca buku-buku lainnya.Discoid lupus erythematosus showing irregular focal epithelial hyperplasia and follicular plugging underlying corium.
We are looking for contributors to author, edit, and peer review our vast library of review articles and multiple choice questions.
In an autopsy study, histological abnormalities were found in the bladder wall of an SLE patient who did not have lower urinary tract symptoms, showing that a silent progression of the disease is possible [ 10 ]. For example, there are three subspecies of Grevillea victoriae. Since then, the majority of pharmacogenetic studies of Carbohydrates and Lipids Last Updated on Mon, 17 Sep Monoclonal Antibodies There seems to be no reason in principle why the immune system should not see the more hydrophilic portions of lipid-containing molecules, such as hydroxyl, phosphate or carbohydrate groups Bendelac, Sieling et al.