Textbook of Biochemistry with Clinical Correlations Edited by Thomas M Devlin. pp John Wiley & Sons, New York. £ ISBN 0 - 4 7 1. Article in Biochemistry and Molecular Biology Education 30(4) - The leucine zipper: a hypothetical structure common to a new class of DNA-binding proteins. sous la direction deThomas M. Devlin, Textbook of biochemistry with clinical correlations £ 26, Page iii. Textbook of Biochemistry with Clinical Correlations: Fourth Edition. Edited by. Thomas M. Devlin, Ph.D. Professor Emeritus. Department of Biochemistry.

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5-DEVLIN'S Textbook of Biochemistry with Clinical ehab Aboueladab. This document is currently being converted. Please check back in a few. BIOCHEMICAL SOCIETY TRANSACTIONS. Textbook of Biochemistry with Clinical Correlations. T. M. DEVLIN (Editor). John Wiley and Sons, Chichester, by Thomas M. Devlin January A comprehensive and fully updated edition filled with over clinical correlations This book Textbook of Biochemistry with Clinical Correlations, 7th Edition PDF MB Password: Help.

Most students, including medical students, would also benefit from problems at the ends of the chapters. Overall I recommend this book as a medical school text and as an excellent reference. It has been very useful to me in preparing my own lectures for undergraduates.

Richard A Paselk Convincing preclinical medical students of the importance of a sound grounding in basic biochemistry for understanding human disease and clinical medicine is often very difficult with the currently available biochemical textbooks. Thomas Devlin and his twentyone co-authors aimed to produce a textbook for medical students in which biochemical events at the cellular level are related to physiological processes in the whole animal and the relevance of topics to disease problems is emphasised throughout.

These correlations cover a considerable range, describing the biochemistry of disease states, biochemical actions of antibiotics and drugs and use of biochemical tests in diagnosis.

Often the same clinical condition, eg diabetes, thalassaemia, gout, is used to illustrate different points in separate chapters. This approach is attractive and for the most part these correlations succeed, but there are some surprising omissions and others are rather contrived. Besides the clinical correlations there are other useful features particularly welcome for medical s t u d e n t s - the sections on metabolic interrelationships, nutrition, metabolism of individual tissues, pH regulation, gas transport and genetic engineering.

The basic biochemistry is sound and well-written, except for one or two chapters, and there is adequate crossreferencing. However, while this is an attractive book for medical students there are defects.

Generally there is too much detail for British preclinical courses. The photographs and diagrams black-and-white only compare unfavourably with competing biochemistry books and the Index could be better for such a complex book where many topics cut across several sections.

If the proposed paper-bound edition January is very substantially cheaper, then it will be worth downloading. S J Higgins himself into the sort of muddle considered reprehensible in an undergraduate biochemistry student. The next paragraph tells us that a plot of reaction rate against substrate concentration allows the rate constants to be determined, but unfortunately the method of achieving this useful and remarkable feat is not given.

I have concentrated on the small part of the book that is concerned with what I know most about, because I feel that if a book cannot give a clear and accurate account of what I know already it is unwise to trust what it says about anything else. Perhaps the author is stronger on thermodynamics than on kinetics, but I doubt it. It is not obvious, for example, that he has noticed that most biological processes occur at constant pressure in the liquid phase, rather than at constant volume in the gas phase.

So when enthalpy and the Gibbs energy are mentioned at all they are treated as an afterthought and not as quantities that are central to the whole subject. The book is proudly described as a 'second, corrected and updated edition', though it contains virtually no references to modern experimental work in biology or biochemistry and refers, for example, to the unit membrane model of Danielli and Davson as 'generally accepted'. What the book must have been like before it was updated beggars the imagination.

Springer-Verlag, Berlin.

DM This book is intended for both physicists and nonphysicists, but I think that most biochemists will learn nothing from it and that physicists interested in applying their knowledge to biological systems would do better to learn something about biological systems first.

When they have done so they will not need this book.

Biophysics is a discipline that I approach with caution, because too often it seems to be a refuge for inadequate physicists who see themselves as missionaries among the head-hunters of humbler sciences. Although I can understand little of what they write, when I do understand I often find incorrect or trivial ideas lurking in the thickets of pretentious mathematics.

The first detailed section of the book is devoted to MichaelisMenten kinetics, a topic most biochemists are reasonably familiar with, but Schnakenberg's treatment is not illuminating. The general obscurity is partly the result of using unfamiliar and sometimes undefined symbolism, and I wonder what advantage J has over v as a symbol for reaction rate, for example. The failure to explain things adequately in the text is more important, as is the number of elementary errors. The second equation in the book is dimensionally inconsistent, and the discussion of the justification for neglecting the reverse reaction in initial-rate studies is wrong.

One may neglect it if the product concentration is negligible, or if the relevant rate constant is zero, two possibilities that are completely independent, both logically and in practice: The first five chapters thus lay out the overall structural and functional aspects of biochemical systems.

Textbook of Biochemistry with Clinical Correlations 7e – Thomas M. Devlin

An orientation towards clinical biochemistry in these chapters is obvious in the selection of examples the pH values of human fluids, electrophoresis of serum proteins, ion exchange chromatography of hemoglobin, chromatographic finger-prints of Hb digests, isozyme assays etc and the proteins chosen for detailed examination hemoglobin, immunoglobulins, serum lipoproteins.

This orientation, along with the brief descriptions of the many techniques of biochemistry and the many figures illustrating clinical data, should make these valuable reference chapters for the Medical Student. And it should motivate these students with the obvious value of this material.

The discussion of metabolism then begins with a chapter on bioenergetics and oxidative metabolism, followed by two chapters each on carbohydrates, lipids and amino acids; and a single chapter each on purines and pyrimidines, and on metabolic interrelationships. I really enjoyed these chapters. They are rather light on detailed chemistry and enzyme mechanisms, but they are excellent for metabolic regulation, pathway localization and metabolic variations of tissues. The consistent discussion of regulation in a single organism, man, is truly a strong point.

Many texts present regulatory features from a variety of organisms, which I often find confusing and even educationally counterproductive. There are, after all, many optimal ways to regulate a complex system such as a living organism.

To understand the principles and applications of regulatory concepts it is better to see how a single system operates, then one can carry over to other systems.

Many texts also tend to gloss over tissue differences. Dr Devlin's book is refreshing in consistently pointing out these differences. Thus discussion of glycolysis includes a lovely figure illustrating glucose metabolism in RBCs, brain, muscle, adipose ceils, and liver parenchymal ceils. Knowledge of these tissue variations gives a qualitatively different and expanded perspective of the metabolism of the whole organism, versus the naive view which can arise from many texts.

The instructor can also use some of the 'Clinical Correlations' to demonstrate aspects of regulation, tissue variability etc. My students were amazed to see how the interrelatedness of biochemical systems leads to the final consequences of Fructose Intolerance. Thus chapter 14 discusses tissue interrelationships during various metabolic states, while chapters 15 and 16 discuss the biochemistry of various hormones, including their biosynthesis and modes of action.

DNA, RNA, protein biosynthesis and genetic regulation are given a thorough and, to the extent possible in these rapidlydeveloping fields, up-to-date treatment in four chapters. Both prokaryotic and eukaryotic systems are treated, a necessary inconsistency compared to the rest of the book, but a requirement to give an adequate treatment of these topics.

These first 20 chapters constitute an essentially complete biochemistry text. However there are an additional six chapters covering some aspects of physiological chemistry: the metabolism of individual tissues, iron and heme metabolism, blood gases and pH, digestion and absorption of nutrients, and nutrition. These chapters vary considerably in biochemical content. There is little new here, but it is convenient.

Textbook of Biochemistry with Clinical Correlations, 7th Edition

On the other hand there is much new biochemistry in the chapter on iron and heme metabolism. Though I found the information in these chapters interesting, I must ask whether they are necessary in a text already pages long without this material. And much of it will, after all, appear in other required coursework of the medical or biology student. The lack of distinction between these two concepts in one of the most widespread misunderstandings among students.

Several very nice diagrams to illustrate this point have been published in Biochemistry and Molecular Biology Education , including one by Punekar [ 3 ].

My plea is to be clear to the uninitiated, as well as accurate. Despite my critical comments, I believe this text fills an important niche, and in that niche it is very well done.

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Textbook of Biochemistry:They are rather light on detailed chemistry and enzyme mechanisms, but they are excellent for metabolic regulation, pathway localization and metabolic variations of tissues.

The second equation in the book is dimensionally inconsistent, and the discussion of the justification for neglecting the reverse reaction in initial-rate studies is wrong. Textbook of Biochemistry: Though I found the information in these chapters interesting, I must ask whether they are necessary in a text already pages long without this material.

For students in these courses the book has some advantages and some major deficiencies. Request Username Can't sign in? Sufficient references are provided so that the interested student can look further into the literature on the diseases. These chapters vary considerably in biochemical content.

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