PDF(doxylamine + pyridoxine): Learn about PDF's Dosage, Side Effects and indications. Click here to view doxylamine + pyridoxine prescribing information, dosage, adverse drug reactions CIMS Class · Antiemetics Drug Index A to Z. Nowadays, online drug sellers like bestthing.info and bestthing.info provide most of the info we need. Still, this book will be useful when internet is not available. Indian approved drugs in Latest United States FDA Approved drugs - CIMS Abbreviation Index MIMS Abbreviation Index Therapeutic Classes of.
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Also visit my Other Post Indian Drugs Brand Names Free Android Mobile Application -edT (E Drug Today). This the most expected mobile. For over 50 years, MIMS has provided trusted and relevant clinical information for over two million healthcare professionals in Asia. Designed for busy. Publication date Quarterly The Monthly Index of Medical Specialities or MIMS is a pharmaceutical prescribing reference guide published in the.
Account Options Sign in. Top Charts. New Releases. Add to Wishlist. Drugs Book is mobile drug application with more than entries of drug data. Drugs information including name, synonym, group, ATC code, CAS number, description, indication, pharmacodynamics, mechanism of action, classification, categories, toxicity, experimental properties, absorption, half-life, dosage, drug interaction, food interaction, and references.
This application can be used online or offline without structure information. If you have any feedback or support, please contact us: Algorithmind Dev - algorithmind. Reviews Review Policy. View details. Flag as inappropriate. Borneo IT See more. Pharmacy Dictionary Offline. Drug Interactions Probenecid decreases urinary excretion and increases half-life. Y-site incompatibility: Belongs to the class of antiinfectives. Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes.
Belongs to the class of topical antivirals Classification used in the treatment of dermatological diseases. Note that there are some more drugs interacting with aciclovir aciclovir further details are available in official CIMS India aciclovir aciclovir brands available in India Always prescribe with Generic Name: Belongs to the class of nucleosides and nucleotides excluding reverse transcriptase inhibitors.
Used in the treatment of eye infections. ACIV tab. LOVIR tab. ZOVIR tab. ACV tab. ACV vial. CIVIR dispertab. OVIR vial. Usual range: Oral Severe psoriasis Adult: Oral Severe lichen planus Adult: Oral Congenital icthyosis Adult: Max dose: Overdosage Symptoms are identical to acute hypervitaminosis A.
Contraindications Pregnancy before the start. Contraindicated in pregnancy L. Special Female patients to avoid alcohol during and 2 mth after Precautions treatment. The drug is contraindicated in women who are or may become pregnant. Hepatic and renal impairment. Concomitant use with tetracycline. CNS disturbances. Concomitant use of microdised progestin oral contraceptives. Radiographic treatment for prolonged therapy.
Drug Interactions Concomitant use with keratolytics or high dose vitamin A. Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both. GI disturbances. Belongs to the class of systemic retinoids used in the treatment of psoriasis. Avoid blood donation during therapy or at least yr after stopping therapy.
Adverse Drug Dryness of mucous membranes and skin. Lab Interference Elevation of liver enzymes. Monitor plasma lipid and glucose levels especially diabetics regularly. Reduces anticoagulant effect of coumarins e. Severe headache. Food Interaction Co-administration with food may increase oral bioavailability. Mechanism of Acitretin is an active metabolite of etretinate but its Action mechanism of action is unknown. Concomitant use of methotrexate can potentiate hepatotoxicty.
Monitor LFTs. Note that there are some more drugs interacting with acitretin acitretin acitretin brands available in India Always prescribe with Generic Name: Drug Interactions Other cardiotoxic drugs e. Terminal elimination half-life: About 3 hr. Mechanism of Aclarubicin is an anthracycline. Alopoecia rare. Rapidly distributed into tissues after IV admin. Reactions bone-marrow suppression. Cardiotoxicity rare.
Extensively metabolised. Contraindications Pregnancy. Lab Interference Elevated bilirubin level. Triphasic clearance. Special Myocardial irradiation and use of radiotherapy. Cytotoxic Chemotherapy aclarubicin P. CV disease. Excreted in urine mainly as metabolites. Hepatic or Precautions renal impairment. Belongs to the class of cytotoxic antibiotics. Used in the treatment of cancer. Special Patients with sunburn.
Caution when used during pregnancy L. Keep away from the eyes. Mechanism of Adapalene binds to specific retinoic acid nuclear receptors Action which normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Use with caution with preparations containing sulfur. Apply thinly onto affected areas once daily at night after cleansing. Do not apply to cuts. Avoid Precautions excessive exposure to sunlight or UV irradiation.
Acne Treatment Preparations adapalene P. Reactions sensations of stinging and burning. Adverse Drug Mild skin irritation. Drug Interactions Increased irritation may occur with medicated or abrasive soaps. Belongs to the class of topical retinoid preparations used in the treatment of acne.
Minimal topical. APGEL gel. ROZAC gel. FEIZ cream. Adapalene binds to specific retinoic acid nuclear receptors which normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Lactic acidosis. Increased risk of hepatotoxicity in females. Discontinue therapy if liver function worsens. Monitor renal function every 3 mth. HIV Precautions antibody testing to be performed before initiation due to possible resistance development in untreated HIV infection.
Overdosage Monitor for signs of toxicity. Antivirals adefovir dipivoxil P. Reactions asthenia. Monitor hepatic function for several mth in patients whose antihepatitis therapy is discontinued as acute exacerbations of hepatitis may occur.
Haemodialysis patients: Special Pregnancy. Contraindications Lactation. Mechanism of Adefovir dipivoxil is an acyclic nucleoside reverse transciptase Action inhibitor. Ibuprofenincreases bioavailability of adefovir. It can be used in patients with lamivudine-resistant hepatitis B. Food Interaction Increased risk of hepatotoxicty with alcohol in hepatitis B infection.
Plasma concentration peaks after 0. Rapidly converted to adefovir after oral admin. Widely distributed to body tissues. Belongs to the class of Classification nucleoside and nucleotide reverse transcriptase inhibitors. The diester function is hydrolyzed and subsequently phosphorylated to the active adefovir diphosphate. Protein binding: Note that there are some more drugs interacting with adefovir dipivoxil adefovir dipivoxil adefovir dipivoxil brands available in India Always prescribe with Generic Name: Drug Interactions Increased risk of nephrotoxicity with nephrotoxic drugs e.
Contraindications 2nd or 3rd degree AV block and sick sinus syndrome unless pacemaker fitted. Inject radionuclide 3 minute after infusion. Max Dosage: Intravenous Myocardial imaging Adult: Avoid increments if high level AV block occurs at any particular dose. Cardiac Drugs adenosine P. Intravenous Paroxysmal supraventricular tachycardia Adult: Mechanism of Adenosine acts rapidly to slow down conduction through the Action AV node via the A1 receptors.
Adenosine effects are potentiated by dipyridamole. Adverse Drug Facial flushing. Belongs to the class of other preparations used in cardiac therapy. Concomitant carbamazepine may increase the risk of heart block. It also mediates peripheral and coronary vasodilatation by stimulating the A2 receptors.
Metabolised to adenosine monophosphate and inosine. ECG changes suggestive of rhythm disturbances. Rapidly taken up into the erythrocytes and vascular endothelial cells. Drug Interactions Adenosine effects antagonised by methylxanthines like caffeine. Reactions sweating. Note that there are some more drugs interacting with adenosine adenosine adenosine brands available in India Always prescribe with Generic Name: Plasma half-life: Oral Enterobiasis Adult: Treatment cycles may need to be continued for mth or yr until complete eradication of parasites.
Oral Ascariasis Adult: For alveolar echinococcosis. Oral Neurocysticercosis Adult: For cystic echinococcosis. Oral Hookworm infections Adult: Anthelmintics albendazole P. Enterobiasis Adult: Serum levels are increased if taken with dexamethasone and praziquantel agent. Poorly absorbed from the GI tract oral.
Oral Strongyloidiasis Adult: Administer within 7 Precautions days of start of normal menstruation in women of childbearing age.
Perform liver function tests and blood counts before and every 2 wk during high dose therapy of hydatid disease. Contraindications Pregnancy and lactation.
Oral Giardiasis Adult: It inhibits tubulin polymerization in the parasite and blocks glucose uptake. Adequate nonhormonal contraceptive measures must be taken during and for 1 mth after therapy. Special Monitor blood counts and liver function.
Drug Interactions Cimetidine increases albendazole metabolism. Susceptible parasites include hookworm. Overdosage Symptomatic and supportive measures are advised. Mechanism of Albendazole exhibits a broad-spectrum anthelmintic activity Action showing vermicidal.
Adverse Drug GI discomfort. Bone marrow depression. ALZAD tab. AL tab. Extensive hepatic first-pass metabolism. ALBEX tab. AH-1 susp. Note that there are some more drugs interacting with albendazole albendazole further details are available in official CIMS India albendazole albendazole brands available in India Always prescribe with Generic Name: ALBOL tab.
BANDY susp. ABZ susp. ABIDE tab.
EBEX chewable tab. ALZOL tab. ALIO tab. Belongs to the class of Classification benzimidazole derivative agents used as antinematodal. C-TROP susp. EBEX susp. C-BEND tab.
BIWOM susp. ABIDE syr. C-BAND film-coated tab. DAZO tab. AH-1 chewable tab. AL susp. BANDY tab. ALBEX susp. E-BEND tab. ALZAD susp. C-TROP tab. BIWOM tab. BAND tab. D-WORM syr. Widely distributed.
ABZ chewable tab. Via bile. C-BEND syr. XENDA susp.
Veterinary Drug Index
ODAL tab. X-WORM susp. ZAA susp. ZAA tab. OLBAN tab. REALB syr. OBEN syr. ODAL susp. X-WORM tab. R-BEN susp. N-BEND susp. REALB tab. REZOL tab. OLBAN susp. WONIL tab. WONIL susp.
HYMIN susp. FOBEN chewable tab. XENDA tab. HYMIN tab. FOBEN susp. Oral Paget's disease of bone Adult: Swallow whole. Milk or antacids should be given to bind alendronate. Should not induce. Overdosage Symptoms may include hypocalcaemia. Oral Corticosteroid-induced osteoporosis Adult: Treatment and prevention: Administration Should be taken on an empty stomach.
Oral Prophylaxis of postmenopausal osteoporosis Adult: Agents Affecting Bone Metabolism alendronic acid P. Reactions heartburn. Drug Interactions Concomitant iron.
Dialysis would not be beneficial. Poorly absorbed from the GIT oral. Should not induce vomiting due to the risk of oesophageal irritation. Note that there are some more drugs interacting with alendronic acid alendronic acid. Contraindications Hypocalcaemia. Patient should remain fully upright.
Special Upper GI disorders discontinue if symptoms worsen. To be taken half an hr before breakfast and remain upright for at least 30 minutes after admin. Adverse Drug Oesophagitis. Mechanism of Alendronic acid reduces bone resorption by inhibiting the Action action of osteoclasts.
Food Interaction Food. Correct vitamin D and calcium deficiency before starting therapy. Symptoms may include hypocalcaemia. Used in the treatment of bone diseases.
Belongs to the class of bisphosphonates. In hypercalcaemic dialysis patients. In case of renal impairment. Treatment is symptomatic and supportive. Overdosage Symptoms may include anorexia. Rickets or osteomalacia. Adverse Drug Anorexia. Hypoparathyroidism Adult: Consider treatment with glucocorticosteroids. Ensure patient is well hydrated by i. Monitor Precautions serum levels of calcium in patients with renal failure. Caution in hypercalciuria esp in those with history of renal calculi.
ECG especially in patients on digitalis. Avoid in patients with hypersensitivity to inj. Premature infants and neonates: Stop admin of alfacalcidol.
Renal osteodystrophy. Contraindications Hypercalcaemia. Monitor electrolytes. Used as dietary supplements. Note that there are some more drugs interacting with alfacalcidol alfacalcidol alfacalcidol brands available in India Always prescribe with Generic Name: Faeces and urine small amounts.
Belongs to the class of vitamin D and Classification analogues. Some antiepileptics e. Adequately absorbed from the GI tract oral. Adipose and muscle tissue.
Mechanism of Alfacalcidol is a precursor of the active calcitriol. It does not Action require renal hydroxylation but requires hydroxylation in the liver for conversion to calcitriol.
Specific to a-globulin. Drug Interactions Thiazides may increase the risk of hypercalcaemia. ALFA-D3 tab. ALFEX cap. ALCAL cap. GSCAL tab. Adverse Drug Drowsiness. Mild-moderate impairment: Initiate with 2.
Contraindications Severe hepatic impairment. Reactions depression. Special Elderly. Monitor BP regularly. Maintain patient in supine position to restore BP. Adjust dose according to response. Modified-release preparations are not recommended. May affect ability to drive or operate machinery. Overdosage May lead to hypotension. Monitor renal function.
Belongs to the class of Classification alpha-adrenoreceptor antagonists. Reduced serum levels when used with CYP3A4 inducers e. CYP3A4 inhibitors e. Extensively metabolised in the liver. Note that there are some more drugs interacting with alfuzosin alfuzosin further details are available in official CIMS India alfuzosin alfuzosin brands available in India Always prescribe with Generic Name: Mechanism of Alfuzosin is a quinazoline-derivative which exhibits selectivity Action for a1 -adrenergic receptors in the lower urinary tract.
FUAL tab. Metabolites are mainly excreted in faeces via bile.
Concurrent use with potent CYP3A4 inhibitors e. Blockade of these adrenoreceptors causes relaxation of smooth muscle in the bladder neck and prostate. EFZU extentab. Used in the treatment of benign prostatic hypertrophy. Readily absorbed after oral admin. Up to mg may be taken as a single dose. Dose reduction may be needed. Severe impairment: Monitor liver function regularly. Oral Gout Adult: Max initial dose: Ensure adequate fluid intake.
Dose is adjusted based on subsequent hr urinary urateexcretion. Ensure sufficient fluid intake to produce a daily urinary output of at least 2 L and maintenance of a neutral. Therapy should be started hr before initiating the treatment.
Oral Prophylaxis of uric acid nephropathy associated with cancer therapy Adult: Oral Recurrent calcium oxalate stones Adult: Intravenous Cancer therapy-induced hyperuricaemia Adult: Maintenance for patients with hyperuricaemia secondary to cancer or cancer therapy: Dose is titrated based on response.
GI disorders. Take immediately after meals. Dose can be given as a single dose or equally divided doses at Withdraw immediately when sensitivity skin rash. Reactions vomiting. Adverse Drug Rash. Prophylactically with an Precautions anti-inflammatory or colchicine for at least 1 mth. Therapy should be started hr before initiating the chemotherapy treatment. Amikacin sulfate.
Special Ensure adequate fluid intake. May increase serum levels of ciclosporin. Inhibition of xanthine oxidase leads to accumulation of its substrates hypoxanthine and xanthine but since their renal clearance is more than 10 times that of uric acid. Converted to oxipurinol alloxanthine. Mechanism of Allopurinol is an inhibitor of the enzyme xanthine oxidase Action which converts hypoxanthine to xanthine then uric acid. After reconstitution: May prolong half-life of chlorpropamide and dicumarol.
Drug Interactions Increased risk of skin rash when used with ampicillin or amoxicillin. May increase bone marrow depression when used with cyclophosphamide Potentially Fatal: Increased haematological effects of azathioprine and mercaptopurine when co-administered with allopurinol.
Powder for inj: The reduced production of uric acid relieves all symptoms associated with hyperuricaemia and gout. Enters breast milk. Urine as unchanged drug and metabolite. Note that there are some more drugs interacting with allopurinol allopurinol further details are available in official CIMS India allopurinol.
Belongs to the class of preparations Classification inhibiting uric acid production. Used in the treatment of gout. Solution should be used within 10 hr of preparation.
URLO tab. ORLU tab. ALUR tab. Z-NOL tab. GURIK tab. Sudden withdrawal of allyloestrenol should be avoided as it leads to intermittent breakthrough bleed lactation. Contraindicated in preg L.
Adverse Drug GI disturbances. Belongs to the class of estren derivative progestoge Classification used in progestogenic hormone preparations. It prepares the uterus fo Action receiving the fertilised ovum and suppresses uterine motility. Increased ciclosporin concentration. Drug Interactions Enhanced clearance with enzyme-inducing drugs eg.
Special Discontinue medications if there is sudden partial or complete loss of vision. Lab Interference Alterations in lipid profile and liver function tests. Mechanism of Allylestrenol is similar to that of natural progesterone.
History of depression. Precautions proptosis or diplopia. My impair ability to drive operate machinery. Ket azole may increase bioavailability of progesterone. IUGR tab. ANIN tab. Note that there are some more drugs interacting with allylestrenol allylestrenol allylestrenol brands available in India Always prescribe with Generic Name: Take 30 mins before meals. May lower blood glucose. Special Pregnancy and lactation. As a racemic mixture: It is also known as thioctic acid.
Monitor Precautions blood glucose levels regularly. Mechanism of Alpha-lipoic acid has antioxidant activity and activity in Action enhancing biological energy production. Anxiolytics alprazolam P. Avoid in severe impairment. Flumazenil may be used for complete or partial reversal of the sedative effects of benzodiazepines and may be used when an overdose with a benzodiazepine is known or suspected.
Oral Panic attacks Adult: Up to 10 mg daily. Monitor respiration. Contraindications Acute narrow-angle glaucoma. Dialysis is of limited value. Muscle weakness. General supportive measures and immediate gastric lavage may be recommended.
Precautions Geriatric or debilitated patients. Special Dosage reduction or gradual withdrawal. If hypotension occurs. Mechanism of Alprazolam has anxiolytic. Increased neuronal permeability to chloride ions thus results in hyperpolarisation and stabilisation. It binds to the? Alprazolam enhances activity of imipramine anddesipramine. There is positive evidence of human foetal risk. Adverse Drug Psychological and physical dependence.
Cimetidine and fluoxetine reduce the clearance of alprazolam. Used in the management of anxiety. Belongs to the class of Classification benzodiazepine derivatives anxiolytics.
Urine as unchanged drug and metabolites. Well absorbed from the GIT oral. Geriatric or debilitated patients. Action antidepressant and sleep-modifying effects. Note that there are some more drugs interacting with alprazolam alprazolam further details are available in official CIMS India alprazolam.
Blood dyscrasias. Dosage reduction or gradual withdrawal. BELFA tab. Q-REST tab. TAGAT tab. ANXIT tab. PACYL tab. AZO-O tab. DALP tab. MCALM tab.
L-PEEZ tab. TRIKA tab. ALPRA tab. ALZEX tab. AZO-S tab. ALP tab. P-KALM tab. NOREX tab. LORAL tab. SOWEL tab. D tab. ALZY tab. ANAX tab. ALP-FT tab. TENAN tab. ALEP tab. RIAN tab. AZO-F tab. ANZI tab. ZAM tab. ALRIF tab. QUIET tab. STS tab. RESTA tab. ALAP tab. D SR-tab. AZOX tab.
ATAM tab. ATEEZ tab. ANZI-P tab. ALPAM tab. ANXYL tab. ZEPRO tab. ZOCAM tab. ZOLIN tab. ZOPIC tab. ZOPAX tab. ZOLAX tab. ZOLAM tab. ZENAX tab. Drugs for Erectile Dysfunction. Intracavernosal Diagnosis of erectile dysfunction Adult: Reduce to the lowest dose necessary to maintain response as soon as possible. Usual maintenance: Once the optimal dose is determined.
Other Cardiovascular Drugs alprostadil P. A dose of mcg may also be administered trans-urethrally. To be injected into a large vein. Intracavernosal Erectile dysfunction Adult: For neurogenic origin e.
Urethral Erectile dysfunction Adult: Initially mcg. Food Interaction Avoid ethanol. Rapidly metabolised by oxidation during passage through the pulmonary circulation. Reactions diarrhoea. Belongs to the class of drugs used in erectile dysfunction. When injected along the penile shaft. Mechanism of Alprostadil causes vasodilation and prevents platelet Action aggregation. Belongs to the class of prostaglandins used in cardiac therapy.
Note that there are some more drugs interacting with alprostadil alprostadil further details are available in official CIMS India alprostadil alprostadil brands available in India Always prescribe with Generic Name: Caution in COPD. Cardiac arrest. This allows blood flow to the lacunar spaces of the penis. Special Neonates receiving PGE1 for more than hr should be Precautions closely monitored for antral hyperplasia and gastric outlet obstruction.
Excreted in urine as metabolites within 24 hr. Adverse Drug Flushing. It has direct effect on the vascular and ductus arteriosus smooth muscle. Usual dose: Not to exceed a total dose of 4 mg. Intravenous Acute massive pulmonary embolism Adult: Total dose: First 10 mg as bolus.
Intravenous Acute ischaemic stroke Adult: To be given within 3 hr of the onset of symptoms: Infuse 0. Injection Clearance of central venous lines Adult: A total dose of mg should be given as soon as possible after the onset of symptoms. For admin within 6 hr of MI: Monitor intracranial Precautions haemorrhage and BP in acute stroke. Storage Injection: Lyophilised product: Reconstitute by adding 50 ml of sterile water for inj without preservatives to a vial containing 50 mg of drug using a large-bore e.
Contraindications Recent surgery or trauma. Final concentration: Renal impairment. Drug Interactions Heparin reduces risk of coronary reocclusion. Increased risk of hemorrhage with warfarin. Reconstituted solution: Use within 8 hr. Lab Interference May interfere with estimation of plasma fibrinogen and other coagulation tests. Mechanism of Alteplase initiates local fibrinolysis and dissolution of clots by Action binding to fibrin in a thrombus and the fibrin-bound plasminogen is converted to plasmin.
Haemorrhage esp with previous trauma or unsuspected underlying cause of bleeding. Adverse Drug Vomiting. Special Children. Prostacyclin and nitrates increase plasma alteplase clearance. Belongs to the class of enzymes. Note that there are some more drugs interacting with alteplase alteplase alteplase brands available in India Always prescribe with Generic Name: Alteplase initiates local fibrinolysis and dissolution of clots by binding to fibrin in a thrombus and the fibrin-bound plasminogen is converted to plasmin.Adverse Drug Flatulence, abdominal pain, distension, diarrhoea, nausea, Reactions vomiting.
Br J Clin Pharmacol. World J Dent 3 4 : COFAL dry syr. Maintenance dose: Severe GI bleeding; nephrotoxicity; blood dyscrasias. Drug Interactions Drugs that may increase blood glucose levels e. Belongs to the class of topical antivirals Classification used in the treatment of dermatological diseases.
Supportive measures are required to restore electrolyte and pH balance. Discontinue therapy if liver function worsens.
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