by Haruki Murakami - Killing Commendatore: A novel (ePub) Download ePub .. by Veronica Roth - The Divergent Series Complete Collection Divergent. FREE EPUB E-BOOK DOWNLOADS: Divergent Series Complete Box Set - Veronica Roth on bestthing.info Descargá gratis el libro Divergent - In Beatrice Prior's dystopian Chicago world, in the Divergent series—dystopian thrillers filled with electrifying decisions.
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Divergent Trilogy has 43 entries in the series. Trilogy (Series). Veronica Roth Author (). cover image of The Divergent Series Complete Collection. Book Info: Divergent ebook. Series: Divergent (Book 1). Author: Veronica Roth. ISBN ISBN Perfect for gift givers, collectors, and fans new to the series, the collection includes Divergent, Insurgent, and Allegiant, as well as bonus content: a page .
Abstract CRISPR DNA arrays of unique spacers separated by identical repeats ensure prokaryotic immunity through specific targeting of foreign nucleic acids complementary to spacers. However, acquisition of different PAM-associated spacers proceeds with markedly different efficiency from the same DNA. We found that during primed adaptation, efficiency of spacer acquisition is strongly negatively affected by the presence of an AAG trinucleotide-a consensus PAM-within the sequence being selected.
No such trend is observed during naive adaptation. The results are consistent with a unidirectional spacer selection process during primed adaptation and provide a specific signature for identification of spacers acquired through primed adaptation in natural populations.
Different fragments are acquired into CRISPR arrays with widely different efficiencies, but the factors responsible are not known.
These results are important because they provide new information on the mechanism of primed spacer acquisition. They add to other previous evidence in the field that pointed out to a "directionality" in the capture of new spacers. Our data strongly suggest that the recognition of an AAG PAM by the interference machinery components prior to spacer capture occludes downstream AAG sequences, thus preventing their recognition by the adaptation machinery.
Methods Enzymol. Epub Dec 1. The DNA interrogation and R-loop formation involve several distinct steps the molecular details of which are not fully understood. Controller protein of restriction-modification system Kpn2I affects transcription of its gene by acting as a transcription elongation roadblock. Abstract C-proteins control restriction-modification R-M systems' genes transcription to ensure sufficient levels of restriction endonuclease to allow protection from foreign DNA while avoiding its modification by excess methyltransferase.
The Kpn2I restriction endonuclease gene is transcribed from a constitutive, weak promoter, which, atypically, is C-protein independent. Kpn2I C-protein C. Kpn2I binds upstream of the strong methyltransferase gene promoter and inhibits it, likely by preventing the interaction of the RNA polymerase sigma subunit with the consensus element.
Diminished transcription from the methyltransferase promoter increases transcription from overlapping divergent C-protein gene promoters. All known C-proteins affect transcription initiation from R-M genes promoters. Uniquely, the C. Kpn2I binding site is located within the coding region of its gene.
Kpn2I acts as a roadblock stalling elongating RNA polymerase and decreasing production of full-length C.
Kpn2I mRNA. Mathematical modeling shows that this unusual mode of regulation leads to the same dynamics of accumulation of R-M gene transcripts as observed in systems where C-proteins act at transcription initiation stage only.
Bioinformatics analyses suggest that transcription regulation through binding of C. Kpn2I-like proteins within the coding regions of their genes may be widespread. Ultrahigh-throughput functional profiling of microbiota communities. Abstract Microbiome spectra serve as critical clues to elucidate the evolutionary biology pathways, potential pathologies, and even behavioral patterns of the host organisms.
Furthermore, exotic sources of microbiota represent an unexplored niche to discover microbial secondary metabolites. However, establishing the bacterial functionality is complicated by an intricate web of interactions inside the microbiome.
We developed uHT quantitative single-cell analysis to estimate antibiotic efficacy toward different microbiomes and used it to determine the activity spectra of Ami toward human and Siberian bear microbiota. Thus, uHT microfluidic droplet platform activity profiling is a powerful tool for discovering antibiotics and quantifying external influences on a microbiome.
RNA Biol. While the Cas12b seed is just five bases long, in contrast to all other effectors characterized to date, the nucleotide base at the site of target cleavage makes a very strong contribution to target binding. Three quarters of a century later, bestselling author Doug Preston joined a team of scientists on a groundbreaking new quest. In he climbed aboard a rickety, single-engine plane carrying the machine that would change everything: In an unexplored valley ringed by steep mountains, that flight revealed the unmistakable image of a sprawling metropolis, tantalizing evidence of not just an undiscovered city but an enigmatic, lost civilization.
Venturing into this raw, treacherous, but breathtakingly beautiful wilderness to confirm the discovery, Preston and the team battled torrential rains, quickmud, disease-carrying insects, jaguars, and deadly snakes. But it wasn't until they returned that tragedy struck: Preston and others found they had contracted in the ruins a horrifying, sometimes lethal-and incurable-disease.
The Lost City of the Monkey God. Review As a longtime fan of the Pendergast series that Douglas Preston writes together with Lincoln Child was I curious to read this non-fiction book about a lost city.
Personally, I find mysteries likes this very intriguing. I mean a lost city that is mentioned in old documents, but no one has found? What's not to like? Expand text… And, what makes this book so fantastic is that Douglas Preston himself was part of the expedition to what could be White City or the Lost City of the Monkey God.
A place where no one has been for centuries, a place with a lot of deadly creatures like the deadly fer-de-lance, one of the most deadly snakes on the planet. The Lost City of the Monkey God captivated me from the beginning, Preston has written a well-researched book, which gives the reader both the historical background as well as the impressions from the expedition.
I always love books that are entertaining and learning as well, and Preston has managed that. The only thing I found a bit dreary was the technical descriptions of the equipment that they used to pinpoint the city, but I got the gist and that was enough for me. I'm just not that interested in technical things so stuff like that always makes me a bit bored.
But, I fully understand the need for it to be included in the story. Especially since it pissed of archaeologists who thinks that it's cheating to use lidar to find lost cities. I loved that part of the story, how petty some archaeologists were.
As much as I enjoyed reading the historical background must I admit that reading about the expedition, how they were the first ones there were very thrilling.
I could easily picture the scenery and I found the discovery of the city and artifacts fascinating. Although I'm not sure I would want to travel there with all the bugs and deadly snakes. The Lost City of the Monkey God was a truly great book. I loved learning more about the history of Honduras and it made me sad to think how the Europeans arrival pretty much killed off most of the natives all over America thanks to the sickness they brought with them.
English Books pinned post 27 Dec In the deadly chaos of the First World War, one horse witnesses the reality of battle from both sides of the trenches. Bombarded by artillery, with bullets knocking riders from his back, Joey tells a powerful story of the truest friendships surviving in terrible times.
One horse has the seen the best and the worst of humanity. The power of war and the beauty of peace. This is his story. The National Theatre production opened in and has enjoyed successful runs in the West End and on Broadway. A great way of introducing young readers to the realities of WWI.
He taught for ten years in both state and private schools and is married with three children and six grandchildren. His first book was published in and he has since published over titles. His books have been translated into over twenty languages. Michael's books have also been adapted for film and the stage, including most recently the National Theatre's enormously successful production of War Horse.
Together with his wife Clare he founded Farms for City Children, an educational charity, in The organisation now runs three farms welcoming over 3, children a year.
Michael was Children's Laureate from War Horse - Michael Morpurgo. Review This book was amazingly emotional and touching! It really played around with my emotions putting happiness and hope in one minute and then sadness and disappointment.
Everyone will love it!!. Luana Costa.
The movie is so beautiful!. English Books pinned post 20 Dec And a secret is eating her family alive… Jenna is given another shot at life when she receives a donor heart from a girl called Callie. But how did she die? Jenna is determined to discover the truth but it could cost her everything; her loved ones, her sanity, even her life … A compelling, gripping psychological thriller with a killer twist from the author of the Number One bestseller The Sister.
What everyone is saying about Louise Jensen: I thought I had it all worked out until I was proven sooo wrong. I neglected all the house work and put off cooking dinner until I was finished … I loved every page. What an amazing debut novel! Full of intense twists! Fantastic book to start off summer reading! Highly recommend. I can't wait for more books to come from Louise Jensen … A well-deserved five stars from me.
Highly recommended!! I was hit again with another twist.
A must read. You have to know what happens and with each page a new idea or theory springs to mind. Nothing compares to the way it turns out. The Gift - Louise Jensen. Review Hells Bells! Expand text… I read the authors debut novel The Sister earlier this year and I thought it was a fantastic read, so I was hoping it would be just as good, but Louise Jensen has surpassed all my expectations with this heart stopping read excuse the pun!
Jenna the protagonist has received a donor heart, as she recuperates from her life saving operation Jenna begins to suffer with irrational thoughts and feelings that appear to centre around Callie the girl whose heart was donated. When I read a psychological thriller I expect the author to emphasise the psychology of their characters and Louise Jensen manages this with aplomb. The Gift explores familiar issues, lies, secrets and protecting those you love, which could have made for a mediocre read, but fortunately the author manages to add originality to these themes, making for a compelling read shrouded in intrigue.
At times I became so caught up in the plot that I found myself jumping at every little sound.
Allegiant (Divergent, Book 3)
English Books pinned post 18 Dec Forty years ago, Israeli psychologists Daniel Kahneman and Amos Tversky wrote a series of breathtakingly original studies undoing our assumptions about the decision-making process.
Their papers showed the ways in which the human mind erred, systematically, when forced to make judgments in uncertain situations. Kahneman and Tversky are more responsible than anybody for the powerful trend to mistrust human intuition and defer to algorithms.
The Undoing Project is about a compelling collaboration between two men who have the dimensions of great literary figures. They became heroes in the university and on the battlefield—both had important careers in the Israeli military—and their research was deeply linked to their extraordinary life experiences. Amos Tversky was a brilliant, self-confident warrior and extrovert, the center of rapt attention in any room; Kahneman, a fugitive from the Nazis in his childhood, was an introvert whose questing self-doubt was the seedbed of his ideas.
They flipped a coin to decide the lead authorship on the first paper they wrote, and simply alternated thereafter.
Hostinger dans le monde entier
This story about the workings of the human mind is explored through the personalities of two fascinating individuals so fundamentally different from each other that they seem unlikely friends or colleagues. Review 4. Absolutely wonderful. The book moves at a brisk pace, never dull, and fleshes out the men behind the scientific work. This vantage point into where Kahneman and Tversky came from, the events that shaped them, their intellectual make-ups, and the alchemy of their partnership is a real treat.
This added depth to the scientists only makes me appreciate their work all the more. Highly recommended for anyone, but especially those who have read Thinking Fast, And Slow, any book on behavioral economics, or students of how human cognition leads us astray. A fantastic book that I couldn't put down.
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English Books pinned post 17 Dec The Constant Soldier has the pace of a thriller with characters and themes that are nuanced and subtle" The Times The pain woke him up. He was grateful for it. The train had stopped and somewhere, up above them, the drone of aircraft engines filled the night sky. He could almost remember her smile. It must be the morphine. He had managed not to think about her for months now.
Paul Brandt, a soldier in the German army, returns wounded and ashamed from the bloody chaos of the Eastern front to find his village home much changed and existing in the dark shadow of an SS rest hut - a luxurious retreat for those who manage the concentration camps, run with the help of a small group of female prisoners who - against all odds - have so far survived the war.
When, by chance, Brandt glimpses one of these prisoners, he realizes that he must find a way to access the hut.
For inside is the woman to whom his fate has been tied since their arrest five years before, and now he must do all he can to protect her. But as the Russian offensive moves ever closer, the days of this rest hut and its SS inhabitants are numbered. And while hope - for Brandt and the female prisoners - grows tantalizingly close, the danger too is now greater than ever.
And, in a forest to the east, a young female Soviet tank driver awaits her orders to advance. I was gripped to the very last page" Antonia Hodgson, award-winning author of A Devil in the Marshalsea "An elegant and powerful novel which sheds light upon a bleak and lesser known period of the war William Ryan has conjured up both a gripping love story and thriller" Richard Foreman, author of Warsaw.
Constant Soldier, The - William Ryan. Expand text… I loved it. William Ryan writes with a simple, elegant and utterly poetic style that just immerses you totally into the reading experience of it. Character study, setting, plot, everything working on every level, that is the bottom line.
That is not technical writing skill that is creative genuis right there. YES its one of those sorry everyone who blames me for their extreme book downloading The story itself is emotive, thought provoking and completely engaging first page to last, I suffered huge amounts of book trauma the good kind a fair bit of fingernail biting and all the rest.
The plot is taut and authentic, the descriptive prose practically flawless — if you are an emotionally charged reader like me you are just going to devour this and if you are of the more practical head screwed on variety the very least that will happen is you will appreciate the skill. Although I dare anyone to come away from The Constant Soldier without at least one pure emotional sense running through them, whatever that may be.
So for that reason I give it a Highly Recommended tag as if that was even close to being enough. English Books pinned post 16 Dec Striking out on her own, she must leave behind her beloved Momma and sister Hazel and takes refuge in a Georgia brothel run by a freewheeling, gun-toting Jewish madam named Cynthia.
Having been taken in as an infant by a free slave named Charles, Josey has never known her mother, who was murdered at her birth. Josey soon becomes caught in the tide of history when news of the Emancipation Proclamation reaches the declining estate and a day of supposed freedom quickly turns into a day of unfathomable violence that will define Josey-and her lost mother-for years to come. Deftly weaving together the stories of Josey and Naomi-who narrates the entire novel unable to leave her daughter alone in the land of the living-Grace is a sweeping, intergenerational saga featuring a group of outcast women during one of the most compelling eras in American history.
It is a universal story of freedom, love, and motherhood, told in a dazzling and original voice set against a rich and transporting historical backdrop. Natashia Deon - Grace. Review Oh, I wish there was a rating above Could I give this a 10? I loved, loved,loved this book.
I have really enjoyed a lot of books recently but none that have pulled me in so deeply,made me care for the characters so intensely or riveted my soul to a story so powerfully.
It is so hard to believe that this is her debut novel.. Grace begins with a murder on an Alabama plantation. I hate to say much more because I don't want to give away any spoilers. Suffice it to say that the story takes place over 30 years, up to the years after the Civil War. How justice, mercy and grace unfold, woven into the plight of women's inferior status make this a book of both fury and tribulations..
If only my heart could handle I would read this again..
English Books pinned post 14 Dec Two years after vanishing into the Sudanese desert, the leader of a British archeological expedition, Professor Harold McCabe, comes stumbling out of the sands, frantic and delirious, but he dies before he can tell his story. The mystery deepens when an autopsy uncovers a bizarre corruption: His strange remains are returned to London for further study, when alarming news arrives from Egypt.
Fearing the worst, a colleague of the professor reaches out to a longtime friend: Painter Crowe, the director of Sigma Force. The call is urgent, for Professor McCabe had vanished into the desert while searching for proof of the ten plagues of Moses. As the pandemic grows, a disturbing question arises. Are those plagues starting again? Before Director Crowe can investigate, a mysterious group of assassins leaves behind a fiery wake of destruction and death, erasing all evidence.
To unravel a secret going back millennia, Director Crowe and Commander Grayson Pierce will be thrust to opposite sides of the globe. One will search for the truth, traveling from the plague-ridden streets of Cairo to a vast ancient tomb buried under the burning sands of the Sudan; the other will struggle to stop a mad genius locked within a remote Arctic engineering complex, risking the lives of all those he holds dear.
Review A mysterious new virus has suddenly been unleashed on the world, but this might not be the first time it has plagued humanity. Instead, the entire group went missing. Several theories arose as to what might have happened to Professor McCabe and the rest of the group, which included his son, Rory.
All of them were put on hold, though, when McCabe himself came stumbling out of the desert ten days later. Unfortunately, he died before he could receive medical help.
It turned out that it was, indeed, Harold McCabe. Their suspicions were confirmed during an autopsy. Additional testing was scheduled, but within twenty-four hours, everyone present inside the exam room during the autopsy fell violently ill. The incident, it turns out, was not contained. Soon the virus, whatever it was, spread around Cairo and beyond.
Scientists quickly learned that the virus was airborne and highly contagious, with a mortality rate similar to ebola.
But beyond that, it was quite unlike anything anyone had ever seen. When clues surfaced suggesting that everything might actually be linked to an old vial of darkened red water collected from the Nile River thousands of years ago, Sigma Force is called in to figure out if the virus is a work of bioterrorism or an act of God.
Mixing historical fiction, lots of science, cutting-edge new weaponry, and another impossible scenario for the brave men and women at Sigma to try and conquer, The Seventh Plague is vintage James Rollins.
Strap in tight, because James Rollins holds nothing back and will leave you breathless. English Books pinned post 12 Dec What results is tragic and riveting, as both men are forced to confront notions of love and betrayal in the face of the vastly different tracks their lives have taken. Sabina Murray - Valiant Gentlemen. Review What happens when the explorers return? Sabrina Murray explores the intimate lives of the men and women who left Europe to explore the world at the turn of the century.
She brings them back to England, to their wives and families and then sends them back out again, always somehow uncomfortable, at home everywhere and nowhere, loving and hating the families that anchor them. Murray probes the moral ambiguities of colonial exploitation and of English mores, while watching the world edge closer and finally into war. English Books pinned post 11 Dec For years Jeanette Winterson has loved writing a new story at Christmas time and here she brings together twelve of her brilliantly imaginative, funny and bold tales.
For the Twelve Days of Christmas-a time of celebration, sharing, and giving-she offers these twelve plus one: These tales give the reader a portal into the spirit of the season, where time slows down and magic starts to happen.
From trees with mysterious powers to a tinsel baby that talks, philosophical fairies to flying dogs, a haunted house and a disappearing train, Winterson's innovative stories encompass the childlike and spooky wonder of Christmas. Perfect for reading by the fire with loved ones, or while traveling home for the holidays.
Enjoy the season of peace and goodwill, mystery, and a little bit of magic courtesy of one of our most fearless and accomplished writers. Review A very unusual Christmas book. Winterson loves Christmas for its reflection, ritual, love and community. The recipes in the book are less about putting on a holiday show and more about how food can help make Christmas and life merrier and brighter. All throughout, there's a bit of history, some autobiography, and this wish: Least favorite: Even someone as English as Winterson should know not to have New Yorkers talk about "fairy lights" and "sledges.
I was wondering If you had another link for this: English Books pinned post 9 Dec She used to work for the U. An expert in her field, she was one of the darkest secrets of an agency so clandestine it doesn't even have a name.
And when they decided she was a liability, they came for her without warning. Now she rarely stays in the same place or uses the same name for long.
They've killed the only other person she trusted, but something she knows still poses a threat. They want her dead, and soon. When her former handler offers her a way out, she realises it's her only chance to erase the giant target on her back. But it means taking one last job for her ex-employers. To her horror, the information she acquires makes her situation even more dangerous. Resolving to meet the threat head-on, she prepares for the toughest fight of her life but finds herself falling for a man who can only complicate her likelihood of survival.
As she sees her choices being rapidly whittled down, she must apply her unique talents in ways she never dreamed of. In this tautly plotted novel, Stephenie Meyer creates a fierce and fascinating new heroine with a very specialised skill set. And she shows once again why she's one of the world's bestselling authors. Final review, first posted on Fantasy Literature: Stephenie Meyer changes it up fairly dramatically in The Chemist , her second adult novel, where there is nary a vampire, werewolf or space alien to be found.
The narrator, a bright, rather repressed molecular biologist, was originally hired by a nameless government agency to do cutting-edge medical research, but ended up being pressured to use her medical skills to create biological compounds that cause severe pain without permanent physical damage, and then to use them for torture-assisted interrogations sanctioned by this agency.
She justified doing this because it was for the purpose of fighting terrorism and major crime. But something she learned made her a liability for the agency: Alex arms herself to the teeth each day, with guns, syringes filled with various useful and often deadly solutions, and readily breakable glass earrings containing a caustic gas. And she sets up an appallingly elaborate booby trap in her apartments before she goes to sleep each night, with a dummy in the bed complete with a fake bewigged head and with wires attached to it that will set off her homemade poison gas if the dummy is disturbed, while she sleeps in the bathtub wearing a gas mask every night.
Her preparations have paid off: If she does this, her contact promises, there will be no more threats to her life from the agency. Knowing it could be a trick, but wishing for some peace in her life, and moved by the threat of a biological attack that could kill hundreds of thousands, Alex takes on the job despite her suspicions.I found Burton so likable that I was suffering when things got complicated for him.
At times the novel meanders too far from its core themes, though perhaps it was a reflection of the main character getting lost in her life as much as the story being lost in itself. The Giver Quartet Omnibus. Abstract vs. If anything, it's this that likens the novel to real life, this feeling of wanting something better for a friend or acquaintance is something we all recognise.
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