Warthin's tumor or cystadenolymphoma (CAL) is a benign salivary gland tumor occurring almost exclusively in the parotid gland. CALs of other. PDF | Warthin tumour is the second most common benign neoplasm of the on April 6, - Published by bestthing.infonloaded from. 1Department Department of Otolaryngology, Hospital de Viladecans, Barcelona, Spain. 2Department of Warthin's tumour (WT) is the second most common cluding repeated percutaneous aspiration, tumorectomy.

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Download PDF. Dong Hoon Os tumores de Warthin são os segundos tumores benignos mais comuns da glândula parótida. Avaliamos as. Comparação de perfis de microRNA entre tumores de glândula salivar benignos (sete adenomas pleomórficos, nove tumores de Warthin). Download PDF. More article Tumor de Warthin gigante. Visits. The patient underwent surgery due to suspicion of parotid Warthin's tumour. We carried.

CT provides reliable information about the location of the tumor.

The treatment of choice for Warthin tumors is surgery. In our hospital, when Warthin tumors were found, surgery was recommended.


Periodic CT confirmation was performed on patients who refused surgery. According to this algorithm, parotid gland surgeries were performed without recurrence except in one case. One patient with recurrence underwent superficial parotidectomy at the 1st surgery. However, the tumor recurred in the same region 9 months later, and it was removed by partial parotidectomy.

Figure 1. Algorithm for the surgical treatment of Warthin tumor of the parotid gland.

Other minor complications, including salivary fistula and hematoma, occurred after only superficial parotidectomy. Both facial dysfunction and minor complications resolved uneventfully. The limitations of this study are the small sample size and a retrospective review. A prospective study including a large sample size is necessary to establish our treatment algorithm for Warthin tumors.

Conclusion We demonstrated that Warthin tumors occurred more frequently in elderly males with a tendency toward bilaterality, and an association with smoking. Our treatment algorithm, depending on the location of tumors and the result of FNAC, can be useful to determine the appropriate extent of surgery for Warthin tumors. Conflicts of interest The authors declare no conflicts of interest.

References A. Teymoortash, C.

Schrader, H. Shimoda, S. Kato, J.


Evidence of lymphangiogenesis in Warthin's tumor of the parotid gland. Oral Oncol, 43 , pp. Etiology There is no consensus regarding the origin of this tumor.

However, the studies by Kotwall [5] , Pinkston and Cole [6] , and Yoo et al. However, only a few well-documented cases of malignant transformation have been reported [10].

Warthin’s tumor of the larynx: a very rare case and systematic review of the literature

Lymphoid stroma often contains many germ centers, which may be the result of an immune response to neoplastic epithelium or may represent residual lymphoid tissue in the lymph nodes partially replaced by neoplastic epithelium [12]. The lymphocyte population is polyclonal, with a predominance of IgA-producing cells.

Bcl-2 also plays a role in the development of adenomas [17]. By reverse transcriptase and nested PCR, all tumors expressed p63 [21]. Beta4-integrin is strongly expressed in all cell basement membrane and intercellular contacts of the epithelium.

Warthin's tumor

E-cadherin and desmoglein-2 are expressed in cell—cell contacts, but not in basal cell—basement membrane connections. HCAM CD44s is expressed in intercellular contacts of both luminal basal cells and monocytic—lymphocytic stroma.

ICAM-1 has weak expression in both luminal and basal epithelial cells and strong expression in the germinal lymphocytic centers.Comparison of plasma samples of benign and malignant tumor group for microRNA expression profiles. Using a threshold of 1. In the future study, a recently developed technique, readout segmented EPI could help to reduce the distortion and to improve the image quality[ 33 , 34 ].

Next, among suspected non-PA cases, WT and non-WT cases were distinguished by evaluation of epidemiology and subsequent 99mTc pertechnetate scintigraphy. If MRI findings for parotid gland tumors show homogenous T2 hyperintensity, well-circumscribed borders and solid contrast enhancement[ 22 ], diagnosis of PA is straightforward.

Histopathology of Warthin tumor in the parotid gland.

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