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This "Customs Tariff /14" has been published, for official use, incorporating changes/ revision on customs rate and other relating provisions applied for. The large disparity between success rates in treatment and observation groups along with the significant dose response to bracing led the Epub Oct A simplified, readable version of the Web Experience Toolkit using HTML5 and LESS.

Loosening was defined as the presence of a radiolucent line larger than 2 mm or as migration of the implants. Operative Technique All procedures were done in two stages. In the first operation, the implant and all cement remnants were removed. This was followed by a standardized radical debridement with removal of all macroscopically suspicious soft tissue and bone.

In all cases, an antibiotic gentamicin -loaded spacer was implanted. In the second operation, the spacer was removed, repeat debridement of the soft tissues and bone was performed, and an arthrodesis nail was implanted with cement.

The spacer was not premanufactured but formed by the surgeon during the operation and included 1 g of gentamicin and 1 g of clindamycin per 40 g of cement. Bone defects were managed with antibiotic-loaded bone cement and not reconstructed with allogenic or vascularized bone grafts.

Comorbidities, pathogen spectrum, previous surgical procedures, and surgery following intramedullary nailing were documented for all patients on the basis of their charts.

Source of Funding No external funding was used for this study. Results Twenty-six patients were treated with intramedullary nailing after septic failure of several revision total knee arthroplasties in the period between and The most common pathogens resulting in reinfection were S.

An above-the-knee amputation was done in three of these patients, the intramedullary nail was changed in nine, and a stable fistula was created in two.

There were no cases of aseptic loosening of the intramedullary implant. The SF score showed decreased values in all dimensions after the knee arthrodesis. Obesity, hypertension, and diabetes mellitus were shown to be definite predictors of reinfection see Appendix. Discussion Management of periprosthetic infection of the knee joint continues to pose a challenge to patients and surgeons.

Many authors have proposed that, if the infection is not suppressed or eradicated after several revision total knee arthroplasties, arthrodesis is a promising procedure 18 , 20 , 25 , This recommendation is not supported by the present study.

The functional outcome scores revealed marked impairment of mobility and quality of life.

Diabetes mellitus, obesity, and hypertension were identified as significant risk factors for persistent infection. Iacono et al. The VAS pain score averaged 1. The mean reduction in lower-limb length was 0.

The higher rate of persistent infections in our study may be the result of the nonstandard definition of infection prior to the AAOS consensus in Conversely, high infection-eradication rates in older publications should be analyzed critically with regard to the definition of a persistent infection.

The success rate of repeated two-stage revision total knee arthroplasties for the treatment of infection is lower than that after the initial revision attempt to eradicate the infection. Nevertheless, Azzam et al.

In a systematic review article, Wu et al. It has been shown that, if an intramedullary nail is coated with antibiotic-impregnated cement, bacteria can form a biofilm on the cement 29 , As a result of modern coupled prosthetic components, including distal femoral and proximal tibial replacements, no compromises in terms of debridement are required today, even with a revision total knee replacement performed because of periprosthetic infection.

So, once again, the intramedullary nail does not offer any biological advantage over revision replacement. In contrast, not only does the regular and desired reduction in limb length accompanied by joint stiffness impair the affected limb, but adjacent joints hip, sacroiliac joint, and lumbar spine undergo increased stress as well 31 , The main limitations of this study, like all other studies of knee arthrodesis for periprosthetic infection available in the literature, are the retrospective design and the limited number of cases.

In conclusion, on the basis of the results described, intramedullary nailing following septic failure of revision arthroplasty must be regarded with skepticism.


Apart from a substantial rate of persistent infections, patients had substantial impairment of their quality of life associated with pain even when the arthrodesis had been successful in eradicating the infection. We therefore cannot recommend knee arthrodesis after septic failure of revision total knee arthroplasty. Repeat revision total knee arthroplasty or amputation should be considered as an alternative therapy in such difficult cases.

Appendix Tables showing patient demographics, functional outcomes, and predictors of reinfection are available with the online version of this article as a data supplement at jbjs. None of the authors, or their institution s , have had any financial relationship, in the thirty-six months prior to submission of this work, with any entity in the biomedical arena that could be perceived to influence or have the potential to influence what is written in this work.

Also, no author has had any other relationships, or has engaged in any other activities, that could be perceived to influence or have the potential to influence what is written in this work. The complete Disclosures of Potential Conflicts of Interest submitted by authors are always provided with the online version of the article. References 1.

Surgical treatment of early wound complications following primary total knee arthroplasty. J Bone Joint Surg Am. January;91 1 Infection following total knee arthroplasty: prevention and management. June 15;93 12 Preventing infection in total joint arthroplasty. December;92 Suppl 2 Infection after total knee arthroplasty.

A retrospective study of the treatment of eighty-one infections. Distinct microbes, metabolites, and ecologies define the microbiome in deficient and proficient mismatch repair colorectal cancers.

Genome Med. J Clin Oncol. DNA mismatch repair protein deficient non-neoplastic colonic crypts: a novel indicator of Lynch syndrome.

A Novel Antibiotic Spacer for Significant Proximal Femoral Loss - Surgical Technique

Mod Pathol. Association analyses of more than , men identify 63 new prostate cancer susceptibility loci. Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.

High-throughput screening of prostate cancer risk loci by single nucleotide polymorphisms sequencing. The primary reconstruction of bones and joints using a combination of endoprosthetic replacements and intercalary prostheses are complex.

Thus, when infection ensues, effective strategies are needed for managing such cases to minimise the loss of prosthesis or amputation [ 1 ]. Infection of the proximal femur in the presence of prosthetic implants can lead to significant functional detriment and frequently necessitates two-stage revision of the components [ 2 - 6 ]. If there is significant involvement of the femoral diaphysis, or a femoral stem is well fixed, radical resection of the proximal femur may be necessary.

In order to optimize wound healing and prevent shortening, a stable antibiotic eluting femoral spacer can be introduced. When bone loss is minimal and muscular attachments are maintained, a simpler Girdlestone procedure with a cement ball or shaped prosthesis can be used.

However, when larger debridements are necessary, achieving length and stability can be challenging. In this article we present the technique and 3 case examples where we have successfully applied this method. We liaise with our microbiology colleagues to tailor the appropriate antibiotic regimen both intravenous and cement.

Theatre equipment is prepared including a large head monoblock hemiarthroplasty such as an Austin-Moore , femoral head sizers and deployment of fluoroscopy. Antibiotics are introduced routinely at induction of anesthesia. The previous wound is opened and dead, dying or infected tissue is debrided Fig. A trochanteric slide osteotomy similar to the technique described by Ganz [ 7 ] is favored to maintain continuity of the abductors with the vastus lateralis.

The femur is resected at the necessary level and any remaining muscle attachments are released. The femur is marked for rotational alignment prior to the femoral osteotomy.

The acetabulum is cleared of any debris and an acetabular reamer is used with caution to induce clean and bleeding surfaces. Post resection of prosthesis and debris.

Note reamed acetabulum on the left. The head of a trial hemiarthroplasty is used to create an articulation for the femoral component whilst it sets, in neutral version Fig. We find that lubricating and twisting the hemiarthroplasty with saline prevents the cement sticking to the prosthesis. Creation of pseudoacetabulum by compressing a 56mm Austin-Moore into the cement. Femoral Preparation Using the preoperative planning and measurements of the excised femoral section calculation of the length to restore is performed.

The length from the centre of rotation of the femoral head to the distal femoral osteotomy site is noted and 7.

Stephen N. Thibodeau, Ph.D.

This nail and a mm cephalomedullary screw are coupled and locked in position using the set screw available from our manufacturer. A line 7. The remaining distal femoral canal is widened with sequential flexible reamers to just beyond the length of nail to be buried distally.

Should there be a substantially longer distal femoral section remaining, a length greater than 7. The rough outline of the femur is formed using mls of cement, with a femoral head formed by hand and sized using the sizing guides to several millimeters in diameter smaller than the chosen hemiarthroplasty Fig.

Rotation of the component is marked and cement is allowed to set prior to trial reduction so as to avoid inducing secondary polymerization between the new femoral head and the pseudoacetabulum. Cement formed around the nail is inserted into the femur. Once the cement has set and the femoral length trialed long enough to avoid shortening of tissues in the interval before second stage revision, but not so long as to put tension on the wound or prevent reduction distal locking is performed in a routine manner with intraoperative fluoroscopic guidance.

Following surgery, patients are permitted to partially weight bear and to commence 6 weeks of tailored intravenous antibiotic therapy as an outpatient. Case 1 Patient 1 is a 59 year old man who had a hybrid THR for osteoarthritis. After 6 years, he developed a spontaneous infection and underwent a 2 stage revision for proven infection Group B Streptococcus. The patient was diagnosed with a recurrent deep infection based on elevated inflammatory markers and abscess formation.

Intraoperatively, a periprosthetic fracture occurred while attempting to remove the well-fixed stem Fig. Pelvic x-ray showing the retained femoral stem prior to the second revision. A decision was reached to return at a later point to sacrifice the proximal femur during the first of another 2 stage revision to a proximal femoral replacement on this occasion.

The patient had debridement and excision of the proximal femur as per this described technique Fig. Postoperative X-rays showing the temporary antibiotic spacer construct.

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Note the antibiotic cement does not surround the nail within the bone, as opposed to a pre-constructed antibiotic nail.This early acting mechanism could guide breeding and selection of high-yield hybrids. J Bone Joint Surg Br ; 83 8 : Biomaterials ; 26 20 : Methods: A 3 case series of such infections leading to extensive loss of the proximal femur is presented.

In the said notification, at various places, references have been made to exemptions contained in erstwhile notification No.

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